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A real-world evidence analysis of the impact of switching from factor VIII to emicizumab prophylaxis in patients with hemophilia A without inhibitors

A real-world evidence analysis of the impact of switching from factor VIII to emicizumab prophylaxis in patients with hemophilia A without inhibitors

by [email protected] | May 5, 2023 | Hematology, Publication

Abstract Background: This study retrospectively compared annualized billed bleed rates (ABRb) in people with hemophilia A (PwHA) without inhibitors who switched from factor VIII (FVIII) prophylaxis to emicizumab. Research design and methods: A real-world comparison...
Prevalence of renal and bone risk factors among individuals prescribed oral pre-exposure prophylaxis for HIV

Prevalence of renal and bone risk factors among individuals prescribed oral pre-exposure prophylaxis for HIV

by [email protected] | Mar 14, 2023 | Infectious Disease, Publication

Abstract   Objectives The only available oral pre-exposure prophylaxis (PrEP) regimens approved in the United States to prevent HIV infection during the period covered by this study were emtricitabine/tenofovir alafenamide (F/TAF) and emtricitabine/tenofovir...

Trajectory of glycated haemoglobin over time, using real-world data, in type 2 diabetes patients with obesity on a U-100 basal-bolus insulin regimen

by [email protected] | Feb 16, 2023 | Endocrine, Publication

Abstract Aims To identify patient clusters with poor glucose control among type 2 diabetes mellitus (T2DM) patients with obesity who are receiving basal-bolus insulin and to identify the potential therapeutic inertia factors associated with poor control. Methods...
A real-world evidence analysis of the impact of switching from factor VIII to emicizumab prophylaxis in patients with hemophilia A without inhibitors

Trends in overall mortality among US veterans with primary myelofibrosis

by [email protected] | Feb 14, 2023 | Cancer (blood), Hematology, Oncology, Publication

ABSTRACT Background: Primary myelofibrosis [PMF] is a myeloproliferative neoplasm associated with reduced overall survival (OS). Management strategies for PMF have evolved over the last two decades, including approval of ruxolitinib as the first Janus kinase 1...

The cost of flares among patients with systemic lupus erythematosus with and without lupus nephritis in the United States

by [email protected] | Feb 14, 2023 | immunology, Publication

Abstract   Objective: Assess healthcare costs associated with systemic lupus erythematosus (SLE) flares among patients with and without lupus nephritis (LN). Methods: This retrospective cohort study used medical and pharmacy claims data from the United...
A real-world evidence analysis of the impact of switching from factor VIII to emicizumab prophylaxis in patients with hemophilia A without inhibitors

Effectiveness and safety of direct oral anticoagulants among patients with non-valvular atrial fibrillation and multimorbidity

by [email protected] | Jan 13, 2023 | Cardiovascular, Publication

Abstract   Background: In the USA, there is a steady rise of atrial fibrillation due to the aging population with increased morbidity. This study evaluated the risk of stroke/systemic embolism (S/SE) and major bleeding (MB) among elderly patients with...
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