The Burden of Hypoxic Respiratory Failure in Preterm and Term/ Near-Term Infants in the United States: 2011-20

A recent study co-authored by STATinMED Research, assessing the the burden of hypoxic respiratory failure in preterm and term/near-term infants, was presented at the Hot Topics in Neonatology Conference in December. [1]

Considering the high prevalence of hypoxic respiratory failure (HRF) in the neonatal intensive care unit (NICU), this study evaluated treatment patterns, healthcare resource utilization (HRU) and charges in preterm and term/near-term (T/NT) infants with HRF in the United States.

A retrospective cohort analysis was conducted in preterms (≤34 weeks of gestation) and T/NTs (>34 weeks of gestation) with HRF/persistent pulmonary hypertension [PPHN; ICD-9-CM: 747.83] in the inpatient setting during 01JAN2011–31OCT2015 using the Vizient database (first hospitalization with HRF/PPHN—index hospitalization). Comorbidities, HRU, charges, and treatments during index hospitalization were compared in preterms and T/NTs.

A total of 504 preterms and 414 T/NTs with HRF/PPHN were included.

Compared to T/NTs, preterms were more likely to have respiratory distress syndrome (69.4% vs 34.5%; P<0.0001), neonatal jaundice (55.4% vs 25.1%; P<0.0001), and anemia of prematurity (49.2% vs 17.9%, P<0.0001).

Preterms had higher HRU including longer inpatient stay (54.1 vs 29.0 days; P<0.0001), time in NICU (34.1 vs 17.5 days; P<0.0001), time on ventilation (4.8 vs 2.2 days; P<0.0001), time on inhaled nitric oxide (8.3 vs 5.9 days; P=0.0017), and were more likely treated with surfactants (71.2% vs 44.7%, P<0.0001). Preterms had higher mortality (30.2% vs 21.3%; P=0.0023), and higher total hospitalization charges ($613,350 vs $422,558; P=0.0002) than T/NTs.

Results from the latest US data underline the significant clinical & economic burden of HRF/PPN in preterm and T/NTs. Given the high unmet medical need, more research is needed to assess best clinical practice-early diagnosis and treatment-for better patient outcomes.

Contact STATinMED Research today to find out how our expertise can help with your next project.

[1] Pandya S, Wang L, Baser O, Wan G, Lovelace B, Potenziano J, Pham AT, Kontekakis A, Huang X. The burden of hypoxic respiratory failure in preemies and neonates in the United States: 2011-2015. Hot Topics in Neonatology. Washington, DC: December 11-13, 2017.  

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  • National Veterans Affairs (VA) Datasets (2012-2016) (Inpatient, Outpatient, Laboratory, Pharmacy Care, Radiology, Vital Signs, Enrollment) 
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